Issue 8, 2011

Gallium (iii)-catalysed bromocyanation of alkynes: regio- and stereoselective synthesis of β-bromo-α,β-unsaturated nitriles

Abstract

Treatment of arylacetylenes and cyanogen bromide in ClCH2CH2Cl with a catalytic amount of GaCl3 afforded (Z)-β-bromoacrylonitriles with high regio- and stereoselectivity.

Graphical abstract: Gallium (iii)-catalysed bromocyanation of alkynes: regio- and stereoselective synthesis of β-bromo-α,β-unsaturated nitriles

Supplementary files

Article information

Article type
Communication
Submitted
13 Oct 2010
Accepted
26 Nov 2010
First published
17 Dec 2010

Chem. Commun., 2011,47, 2375-2377

Gallium (III)-catalysed bromocyanation of alkynes: regio- and stereoselective synthesis of β-bromo-α,β-unsaturated nitriles

M. Murai, R. Hatano, S. Kitabata and K. Ohe, Chem. Commun., 2011, 47, 2375 DOI: 10.1039/C0CC04385K

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