Issue 12, 2011
From the journal:

Chemical Communications

DNA-capped nanoparticles designed for doxorubicindrug delivery†

Colleen M. Alexander,a   Mathew M. Maye*a  and  James C. Dabrowiak*a  

* Corresponding authors

a Department of Chemistry, Syracuse University, 111 College Pl., Syracuse, USA
E-mail: mmmaye@syr.edu, jcdabrow@syr.edu

Abstract

The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.

Graphical abstract: DNA-capped nanoparticles designed for doxorubicin drug delivery

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Article information

DOI
https://doi.org/10.1039/C0CC04916F
Article type
Communication
Submitted
11 Nov 2010
Accepted
11 Jan 2011
First published
01 Feb 2011

Chem. Commun., 2011,47, 3418-3420

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DNA-capped nanoparticles designed for doxorubicin drug delivery

C. M. Alexander, M. M. Maye and J. C. Dabrowiak, Chem. Commun., 2011, 47, 3418 DOI: 10.1039/C0CC04916F

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