Issue 22, 2011
From the journal:

Chemical Communications

Neutravidin coated surfaces for single DNA molecule analysis†

Yoori Kima  and  Kyubong Jo*a  

* Corresponding authors

a Department of Chemistry & Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul, Korea
E-mail: jokyubong@sogang.ac.kr
Fax: +82 2-705-7893
Tel: +82 2-705-8881

Abstract

We present a novel approach for single DNA molecule analysis using neutravidin coated surfaces. DNA molecules are elongated and reversibly immobilized on neutravidin coated surfaces with pH and salt controls. We demonstrate restriction enzyme reactions for optical mapping and ligation for tethered DNA molecules.

Graphical abstract: Neutravidin coated surfaces for single DNA molecule analysis

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Article information

DOI
https://doi.org/10.1039/C0CC05396A
Article type
Communication
Submitted
06 Dec 2010
Accepted
09 Feb 2011
First published
28 Feb 2011

Chem. Commun., 2011,47, 6248-6250

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Neutravidin coated surfaces for single DNA molecule analysis

Y. Kim and K. Jo, Chem. Commun., 2011, 47, 6248 DOI: 10.1039/C0CC05396A

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