Issue 11, 2011
From the journal:

Chemical Communications

Rationally designed fluorescence ‘turn-on’ sensor for Cu2+†

Kyoung Chul Ko,a   Jia-Sheng Wu,b   Hyun Jung Kim,b   Pil Seung Kwon,c   Jong Wan Kim,d   Richard A. Bartsch,e   Jin Yong Lee*a  and  Jong Seung Kim*b  

* Corresponding authors

a Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: jinylee@skku.edu

b Department of Chemistry, Korea University, Seoul 136-701, Republic of Korea
E-mail: jongskim@korea.ac.kr

c Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan 570-750, Korea

d Department of Laboratory Medicine, Dankook University Hospital, Cheonan 330-715, Republic of Korea

e Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79401, USA

Abstract

A rationally designed, coumarin-based fluorescent sensor imino-coumarin (IC) displays high selectivity for Cu2+ over a variety of competing metal ions in aqueous solution with a significant fluorescence increase. DFT/TDDFT calculations support that the fluorescence ‘turn-on’ of IC originates from blocking the electron transfer of the nitrogen lone pair upon complexation with Cu2+. IC was successfully applied to microscopic imaging for detection of Cu2+ in LLC-MK2 cells (in vitro) and several living organs (in vivo).

Graphical abstract: Rationally designed fluorescence ‘turn-on’ sensor for Cu2+

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Article information

DOI
https://doi.org/10.1039/C0CC05421F
Article type
Communication
Submitted
07 Dec 2010
Accepted
06 Jan 2011
First published
31 Jan 2011

Chem. Commun., 2011,47, 3165-3167

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Rationally designed fluorescence ‘turn-on’ sensor for Cu2+

K. C. Ko, J. Wu, H. J. Kim, P. S. Kwon, J. W. Kim, R. A. Bartsch, J. Y. Lee and J. S. Kim, Chem. Commun., 2011, 47, 3165 DOI: 10.1039/C0CC05421F

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