Issue 18, 2011
From the journal:

Chemical Communications

Inhibitors of an essential mycobacterialcell walllipase (Rv3802c) as tuberculosis drug leads†

Nicholas P. West,a   Katie M. Cergol,b   Millie Xue,b   Elizabeth J. Randall,a   Warwick J. Brittonac  and  Richard J. Payne*b  

* Corresponding authors

a Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia

b School of Chemistry, The University of Sydney, NSW 2006, Australia
E-mail: richard.payne@sydney.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 3329

c Sydney Medical School, The University of Sydney, NSW 2006, Australia

Abstract

The first targeted inhibitors of an essential M. tuberculosis cell wall lipase, Rv3802c, are described. Lead compounds exhibited nanomolar inhibition of the enzyme, and encouraging antibacterial activity against M. tuberculosis in vitro, supporting Rv3802c as a novel TB drug target.

Graphical abstract: Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

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Article information

DOI
https://doi.org/10.1039/C0CC05635A
Article type
Communication
Submitted
16 Dec 2010
Accepted
17 Feb 2011
First published
07 Mar 2011

Chem. Commun., 2011,47, 5166-5168

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Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads

N. P. West, K. M. Cergol, M. Xue, E. J. Randall, W. J. Britton and R. J. Payne, Chem. Commun., 2011, 47, 5166 DOI: 10.1039/C0CC05635A

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