Issue 15, 2011

Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill

Abstract

A new, ligand- and solvent-free method for the Huisgen 1,3-dipolar cycloaddition (click reaction) was developed using a planetary ball mill. Besides various alkynes and azides, a propargyl functionalized polymer was converted by mill clicking. Moreover, it was possible to carry out a clickpolymerization in a ball mill.

Graphical abstract: Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill

Supplementary files

Article information

Article type
Communication
Submitted
18 Dec 2010
Accepted
23 Feb 2011
First published
11 Mar 2011

Chem. Commun., 2011,47, 4370-4372

Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill

R. Thorwirth, A. Stolle, B. Ondruschka, A. Wild and U. S. Schubert, Chem. Commun., 2011, 47, 4370 DOI: 10.1039/C0CC05657J

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