Issue 21, 2011

Electrostatic interactions in biological DNA-related systems

Abstract

In this perspective article, we focus on recent developments in the theory of charge effects in biological DNA-related systems. The electrostatic effects on different levels of DNA organization are considered, including the DNA–DNA interactions, DNA complexation with cationic lipid membranes, DNA condensates and DNA-dense cholesteric phases, protein–DNA recognition, DNA wrapping in nucleosomes, and inter-nucleosomal interactions. For these systems, we develop a theoretical framework to describe the physical-chemical mechanisms of structure formation and anticipate some biological consequences. General biophysical principles of DNA compaction in chromatin fibers and DNA spooling inside viral capsids are discussed in the end, with emphasis on electrostatic aspects.

Graphical abstract: Electrostatic interactions in biological DNA-related systems

Article information

Article type
Perspective
Submitted
06 Dec 2010
Accepted
03 Feb 2011
First published
23 Mar 2011

Phys. Chem. Chem. Phys., 2011,13, 9942-9968

Electrostatic interactions in biological DNA-related systems

A. G. Cherstvy, Phys. Chem. Chem. Phys., 2011, 13, 9942 DOI: 10.1039/C0CP02796K

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