A new rhodamine-based chemosensor for Cu2+ and the study of its behaviour in living cells

Liang Huang; Xiao Wang; Guoqiang Xie; Pinxian Xi; Zhengpeng Li; Min Xu; Yongjie Wu; Decheng Bai; Zhengzhi Zeng

doi:10.1039/C0DT00606H

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A new rhodamine-based chemosensor for Cu²⁺ and the study of its behaviour in living cells†

Liang Huang,^a Xiao Wang,^b Guoqiang Xie,^a Pinxian Xi,^a Zhengpeng Li,^a Min Xu,^a Yongjie Wu,^b Decheng Bai^b and Zhengzhi Zeng*^a

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* Corresponding authors

^a Zhengzhi Zeng, State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China
E-mail: zengzhzh@yahoo.com.cn
Fax: 86 931 8912582
Tel: 86 931 8610877

^b Pharmacology Lab of GanSu Province Key Laboratory of Preclinical Study for New Traditional Chinese Medicine, Lanzhou University, Lanzhou, PR China

Abstract

A new rhodamine-based chemosensor (L1) was synthesized, and it exhibits high sensitivity and selectivity for the copper cation over other commonly coexistent metal ions in aqueous solution. Upon the addition of Cu²⁺, the spirolactam ring of L1 was opened and a 1 : 1 metal–ligand complex was formed. Fluorescent imaging of Cu²⁺ in living cells is also successfully demonstrated.

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Article information

DOI: https://doi.org/10.1039/C0DT00606H
Article type: Communication
Submitted: 04 Jun 2010
Accepted: 08 Jul 2010
First published: 30 Jul 2010

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Dalton Trans., 2010,39, 7894-7896

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A new rhodamine-based chemosensor for Cu²⁺ and the study of its behaviour in living cells

L. Huang, X. Wang, G. Xie, P. Xi, Z. Li, M. Xu, Y. Wu, D. Bai and Z. Zeng, Dalton Trans., 2010, 39, 7894 DOI: 10.1039/C0DT00606H

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Dalton Transactions