Issue 23, 2011

One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co

Abstract

We describe the synthesis of the dip (di-picolyl-carboxylate) bifunctional chelator system, capable of fast coordination of Cu2+, 64Cu2+ and Co2+, as well as the [M(CO)3]+-core (M = 99mTc, Re); it displays a variety of binding modes—tridentate when protected, tetradentate when deprotected. Syntheses of both the benzyl-nitro derivative and the benzyl-amino derivatives are described. The latter was coupled to biotin to show the viability of the system for functionalization with biomolecules. Besides coordination chemistry with stable isotopes, we also present labelling data with 64Cu and 99mTc, as well as in vitro stability studies.

Graphical abstract: One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co

Supplementary files

Article information

Article type
Paper
Submitted
23 Oct 2010
Accepted
23 Dec 2010
First published
10 Feb 2011

Dalton Trans., 2011,40, 6253-6259

One to chelate them all: investigation of a versatile, bifunctional chelator for 64Cu, 99mTc, Re and Co

E. Boros, Y. S. Lin, C. L. Ferreira, B. O. Patrick, U. O. Häfeli, M. J. Adam and C. Orvig, Dalton Trans., 2011, 40, 6253 DOI: 10.1039/C0DT01458C

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