Issue 12, 2010
From the journal:

Green Chemistry

A highly efficient copper(i) catalyst for the 1,3-dipolar cycloaddition of azides with terminal and 1-iodoalkynes in water: regioselective synthesis of 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles†‡

Joaquín García-Álvarez,*a   Josefina Díeza  and  José Gimenoa  

* Corresponding authors

a Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Química Organometálica “Enrique Moles” (Unidad Asociada al CSIC), Facultad de Química, Universidad de Oviedo, Oviedo, Spain
E-mail: garciajoaquin@uniovi.es
Fax: +34 985103446
Tel: +34 985102985

Abstract

A new water soluble Cu(I) complex that exhibits a versatile and high catalytic activity in the Huisgen cycloadditions of azides and terminal alkynes in aqueous media under mild conditions is the first well-defined Cu(I) catalyst that is active with 1-iodoalkynes in water under aerobic conditions.

Graphical abstract: A highly efficient copper(i) catalyst for the 1,3-dipolar cycloaddition of azides with terminal and 1-iodoalkynes in water: regioselective synthesis of 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles

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Article information

DOI
https://doi.org/10.1039/C0GC00342E
Article type
Communication
Submitted
20 Jul 2010
Accepted
04 Oct 2010
First published
19 Oct 2010

Green Chem., 2010,12, 2127-2130

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A highly efficient copper(I) catalyst for the 1,3-dipolar cycloaddition of azides with terminal and 1-iodoalkynes in water: regioselective synthesis of 1,4-disubstituted and 1,4,5-trisubstituted 1,2,3-triazoles

J. García-Álvarez, J. Díez and J. Gimeno, Green Chem., 2010, 12, 2127 DOI: 10.1039/C0GC00342E

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