Issue 12, 2010
From the journal:

Green Chemistry

Microwave irradiated C6-functionalization of 6-chloropurine nucleosides with various mild nucleophiles under solvent-free conditions†

Hai-Ming Guo,*a   Peng-Yang Xin,a   Hong-Ying Niu,b   Dong-Chao Wang,a   Yi Jianga  and  Gui-Rong Qu*a  

* Corresponding authors

a College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang, China
E-mail: guohm518@hotmail.com, quguir@sina.com
Fax: +86-3733329276

b School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, China

Abstract

An efficient method for the synthesis of C6-functionalized purine nucleosides was developed via the direct nucleophilic substitution reaction of 6-chloropurine derivatives with various mild nucleophiles. The eco-friendly solvent-free process gave good to high isolated yields within a short reaction time (5 min) under microwave irradiated conditions.

Graphical abstract: Microwave irradiated C6-functionalization of 6-chloropurine nucleosides with various mild nucleophiles under solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/C0GC00517G
Article type
Communication
Submitted
05 Sep 2010
Accepted
20 Oct 2010
First published
03 Nov 2010

Green Chem., 2010,12, 2131-2134

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Microwave irradiated C6-functionalization of 6-chloropurine nucleosides with various mild nucleophiles under solvent-free conditions

H. Guo, P. Xin, H. Niu, D. Wang, Y. Jiang and G. Qu, Green Chem., 2010, 12, 2131 DOI: 10.1039/C0GC00517G

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