Issue 40, 2010

The high functionalization of temperature-responsive culture dishes for establishing advanced cell sheet engineering

Abstract

Our laboratory developed “cell sheet engineering”, which has been applied to regenerative medicine. However, the applications are restricted to the transplants of single-, double-, and triple-layered cell sheets, because of the poor supplies of nutrients and oxygen. To fabricate thicker and dense tissues in vitro, multi-layered cell sheets need to have capillary networks. Additionally, individual tissues found in animal bodies have individual specific micropatterns of cells for expressing their specific functions and characteristics. Therefore, our laboratory has developed various kinds of micropatterned surfaces which could align cells in the shape of micropatterns. In this review, we summarize and discuss patterned surfaces that allow us to perform the high functionalization of temperature-responsive culture dishes for establishing advanced cell sheet engineering.

Graphical abstract: The high functionalization of temperature-responsive culture dishes for establishing advanced cell sheet engineering

Article information

Article type
Feature Article
Submitted
16 Apr 2010
Accepted
26 Jun 2010
First published
31 Aug 2010

J. Mater. Chem., 2010,20, 8768-8775

The high functionalization of temperature-responsive culture dishes for establishing advanced cell sheet engineering

K. Itoga and T. Okano, J. Mater. Chem., 2010, 20, 8768 DOI: 10.1039/C0JM01064B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements