Issue 11, 2011

Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery

Abstract

In this paper, we describe a facile, efficient, and environmentally friendly fabrication of a novel type of magnetic porous metal–organic-framework (MOF)-based nanocomposites that can be potentially used for targeted drug delivery. The magnetic MOF nanocomposites were fabricated by incorporation of Fe3O4 nanorods with nanocrystals of Cu3(BTC)2 (HKUST-1), a three dimensional (3D) MOF with a 3D channel system. The as-synthesized materials exhibited both magnetic characteristics and high porosity, making them excellent candidates for targeted drug delivery systems. An anti-cancer drug acting as a selective cyclooxygenase-2 (COX-2) inhibitor for pancreatic cancer treatment, Nimesulide, was laden into pores of the nanocomposites. These MOF-based magnetic nanocomposites could adsorb up to 0.2 g of Nimesulide per gram of composite, and it took as long as 11 days to complete the drug release in physiological saline at 37 °C.

Graphical abstract: Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery

Article information

Article type
Paper
Submitted
05 Jun 2010
Accepted
06 Dec 2010
First published
28 Jan 2011

J. Mater. Chem., 2011,21, 3843-3848

Facile fabrication of magnetic metal–organic framework nanocomposites for potential targeted drug delivery

F. Ke, Y. Yuan, L. Qiu, Y. Shen, A. Xie, J. Zhu, X. Tian and L. Zhang, J. Mater. Chem., 2011, 21, 3843 DOI: 10.1039/C0JM01770A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements