Issue 8, 2011
From the journal:

Journal of Materials Chemistry

Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy†

Zu-De Qi,‡ac   Dong-Wei Li,‡a   Peng Jiang,a   Feng-Lei Jiang,a   Yue-Sheng Li,ab   Yi Liu,*ab   Wai-Kwok Wong*c  and  Kok-Wai Cheah*d  

* Corresponding authors

a State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE) & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, P. R. China
E-mail: prof.liuyi@263.net
Fax: +86-27-6854067
Tel: +86-27-68756667

b Department of Chemistry and Life Sciences, Xianning University, Xianning, P. R. China

c Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China
E-mail: wkwong@hkbu.edu.hk
Fax: (+852) 3411-7348

d Department of Physics & Centre for Advanced Luminescence Materials, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China
E-mail: kwcheah@hkbu.edu.hk
Fax: (+852) 3411-7348

Abstract

An enhanced photosensitizer combining biocompatible CdSe quantum dots (QDs) with water-soluble porphyrin was synthesized by a facile method. The two photon absorption (TPA) cross-section values of the QDs range from 800 to 2 400 Goeppert–Mayer units (GM), depending on the excitation wavelength, calculated by the standard method using R6G as a reference. The singlet oxygen generation under two-photon excitation (TPE) in the QD–porphyrin system was two times greater than that in the porphyrin solution alone. This study underlines the potential of QD-based photosensitizers for biological applications in TPE photodynamic therapy.

Graphical abstract: Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C0JM03229H
Article type
Communication
Submitted
26 Sep 2010
Accepted
04 Jan 2011
First published
18 Jan 2011

J. Mater. Chem., 2011,21, 2455-2458

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Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

Z. Qi, D. Li, P. Jiang, F. Jiang, Y. Li, Y. Liu, W. Wong and K. Cheah, J. Mater. Chem., 2011, 21, 2455 DOI: 10.1039/C0JM03229H

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