Issue 16, 2011

Nanoreservoir operated by ferrocenyl linker oxidation with molecular oxygen

Abstract

The fabrication and efficient operation of a redox-driven hybrid nanoreservoir that contains the host–guest pair β-cyclodextrin (β-CD) and a ferrocenyl (–Fc) group attached to MCM-41 nanoparticles loaded with rhodamine B are reported. The operation process is based on the effects of pH that is related to the acid catalyzed oxidation of the ferrocenyl group by molecular oxygen (O2). By a thorough set of experiments, the combined effects of pH and oxygen are exploited to control the releasing process. Such experiments characterize the nanoreservoir at various points along the pathway, and show the level of control achieved over the release of rhodamine B. The results show that the same system can operate under different conditions, i.e., at high O2 levels and pH close to the physiological one, where the drug-like molecules could be rapidly released, or at low O2 levels and slightly acidic conditions (pH 5.5 and 6.5), where the drug will be slowly released. In essence, the work presented herein is a step forward in terms of redox-triggered release drug-like molecules from MCM-41.

Graphical abstract: Nanoreservoir operated by ferrocenyl linker oxidation with molecular oxygen

Supplementary files

Article information

Article type
Paper
Submitted
02 Nov 2010
Accepted
04 Feb 2011
First published
03 Mar 2011

J. Mater. Chem., 2011,21, 6034-6039

Nanoreservoir operated by ferrocenyl linker oxidation with molecular oxygen

G. Q. Silveira, M. D. Vargas and C. M. Ronconi, J. Mater. Chem., 2011, 21, 6034 DOI: 10.1039/C0JM03738A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements