Issue 2, 2010

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Abstract

A series of new 1-[di-(4-R-phenyl)-methylidenyl)]-[3]ferrocenophanes, where R = OH, NH2, NHAc, and the phenyl substitution is mixed or identical, are highly antiproliferative against MDA-MB-231 and PC-3 cancer cells, with IC50 values ranging from 0.05–5.6 μM on MDA-MB-231 and 0.02–12.5 μM on PC-3.

Graphical abstract: Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Supplementary files

Article information

Article type
Concise Article
Submitted
08 Mar 2010
Accepted
06 Apr 2010
First published
06 May 2010

Med. Chem. Commun., 2010,1, 149-151

Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

M. Görmen, P. Pigeon, S. Top, A. Vessières, M. Plamont, E. A. Hillard and G. Jaouen, Med. Chem. Commun., 2010, 1, 149 DOI: 10.1039/C0MD00026D

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