Issue 1, 2010
From the journal:

MedChemComm

Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers†

Tianfeng Chen,a   Wen-Jie Mei,*ab   Yum-Shing Wong,c   Jie Liu,a   Yanan Liu,a   Huang-Song Xieb  and  Wen-Jie Zheng*a  

* Corresponding authors

a Department of Chemistry, Jinan University, Guangzhou, China
E-mail: tzhwj@jnu.edu.cn
Fax: +86-20 -8522-1263
Tel: +86-20-8522-1263

b School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, P.R. China
E-mail: wenjiemei@126.com
Fax: +86-20 -8522-1263
Tel: +86-20-8522-1263

c Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, China
E-mail: yumshingwong@cuhk.edu.hk
Fax: +852- 2603-5745
Tel: +852-2609-6389

Abstract

A series of chiral ruthenium polypyridyl complexes have been synthesized and evaluated for their in vitro anticancer activities. Λ-[Ru(bpy)2(o-tFMPIP)]Cl2 · 3H2O was identified as a novel mitochondria-targeted complex, which was able to induce mitochondria-mediated apoptosis in melanoma A375 cells through regulation of Bcl-2 family members and activation of caspases.

Graphical abstract: Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers

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Article information

DOI
https://doi.org/10.1039/C0MD00060D
Article type
Concise Article
Submitted
27 Apr 2010
Accepted
05 Jun 2010
First published
16 Jun 2010

Med. Chem. Commun., 2010,1, 73-75

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Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers

T. Chen, W. Mei, Y. Wong, J. Liu, Y. Liu, H. Xie and W. Zheng, Med. Chem. Commun., 2010, 1, 73 DOI: 10.1039/C0MD00060D

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