Issue 4, 2011

Polyethylenimine–carbon nanotube nanohybrids for siRNA-mediated gene silencing at cellular level

Abstract

Carbon nanotubes (CNTs) covalently modified with low molecular weight polyethylenimine (PEI) are able to bind and deliver siRNA to cells with higher efficacy than a reference lipidic carrier. The performances of the nanohybrid are rationalized by the combination of the cell penetration and endosomal escape properties of CNTs and PEI, respectively.

Graphical abstract: Polyethylenimine–carbon nanotube nanohybrids for siRNA-mediated gene silencing at cellular level

Article information

Article type
Communication
Submitted
19 Dec 2010
Accepted
15 Jan 2011
First published
07 Feb 2011

Nanoscale, 2011,3, 1461-1464

Polyethylenimine–carbon nanotube nanohybrids for siRNA-mediated gene silencing at cellular level

S. Foillard, G. Zuber and E. Doris, Nanoscale, 2011, 3, 1461 DOI: 10.1039/C0NR01005G

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