Issue 10, 2011

Preparation of fluoxetine by multiple flow processing steps

Abstract

Microflow technology is established as a modern and fashionable tool in synthetic organic chemistry, bringing great improvement and potential, on account of a series of advantages over flask methods. The study presented here focuses on the application of flow chemistry process in performing an efficient multiple step syntheses of (±)-fluoxetine as an alternative to conventional synthetic methods, and one of the few examples of total synthesis accomplished by flow technique.

Graphical abstract: Preparation of fluoxetine by multiple flow processing steps

Article information

Article type
Paper
Submitted
20 Oct 2010
Accepted
16 Dec 2010
First published
30 Mar 2011

Org. Biomol. Chem., 2011,9, 3854-3862

Preparation of fluoxetine by multiple flow processing steps

B. Ahmed-Omer and A. J. Sanderson, Org. Biomol. Chem., 2011, 9, 3854 DOI: 10.1039/C0OB00906G

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