Issue 1, 2011

Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases

Abstract

We report our studies on the use of two catalyst systems, based on the ligands BrettPhos and RuPhos, which provide the widest scope for Pd-catalyzed C–N cross-coupling reactions to date. Often low catalyst loadings and short reaction times can be used with functionalized aryl and heteroaryl coupling partners. The reactions are highly robust and can be set up and performed without the use of a glovebox. These catalysts should find wide application in the synthesis of complex molecules including pharmaceuticals, natural products and functional materials.

Graphical abstract: Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases

Supplementary files

Additions and corrections

Article information

Article type
Edge Article
Submitted
08 Jun 2010
Accepted
27 Jul 2010
First published
09 Sep 2010

Chem. Sci., 2011,2, 57-68

Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases

D. Maiti, B. P. Fors, J. L. Henderson, Y. Nakamura and S. L. Buchwald, Chem. Sci., 2011, 2, 57 DOI: 10.1039/C0SC00330A

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