Issue 6, 2011

Engineering DNA aptamers for novel analytical and biomedical applications

Abstract

As an alternative to antibodies, aptamers have shown promising applications in diagnostics and therapeutics. However, different from antibodies, the chemical nature of nucleic acids allows easy synthesis and modification of aptamers. As a result, there are various feasible ways to engineer aptamers with extended bioavailability (e.g., stability and binding affinity in complex environments), regulating ability, and multi-functional properties. In this review, recent advances in rational design and novel functionalization of aptamers, especially DNA aptamers, is described. The broad spectrum of ways for aptamer engineering and applications is paving the way for the future evolution of bioanalytical and biomedical developments.

Graphical abstract: Engineering DNA aptamers for novel analytical and biomedical applications

Article information

Article type
Perspective
Submitted
26 Dec 2010
Accepted
04 Feb 2011
First published
17 Feb 2011

Chem. Sci., 2011,2, 1003-1010

Engineering DNA aptamers for novel analytical and biomedical applications

M. You, Y. Chen, L. Peng, D. Han, B. Yin, B. Ye and W. Tan, Chem. Sci., 2011, 2, 1003 DOI: 10.1039/C0SC00647E

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