Temperature controlled encapsulation and release using partially biodegradable thermo-magneto-sensitive self-rolling tubes

Abstract

We suggest a new approach for controlled encapsulation and release of microparticles, cells and drugs using thin bilayer films of thermoresponsive and biodegradable polymers, which are able to form self-rolling tubes. The magnetic nanoparticles are incorporated in the thermoresponsive layer in order to provide the microtubes sensitivity to magnetic field. We demonstrate reversible rolling and unrolling of the polymer films, reversible capture and release of microparticles in response to change of temperature as well as manipulation of particle-loaded microtubes using external magnetic field. The suggested approach can be successfully implemented for controlled delivery of drugs and cells in living organisms as well as to design scaffolds for tissue engineering.