Issue 5, 2011

Nanoprecipitation and nanoformulation of polymers: from history to powerful possibilities beyond poly(lactic acid)

Abstract

Nanoprecipitation is a facile, mild, and low energy input process for the preparation of polymeric nanoparticles. Basic requirements, as well as common techniques for the self-assembly of non-charged and non-amphiphilic macromolecules into defined nanoparticles are described. At present, the primary focus of polymer nanoprecipitation research lays on poly(lactic acid) (PLA) and its copolymer poly(lactic-co-glycolic acid) (PLGA). This contribution thus emphasises on polymers beyond PLA systems, such as common industrial- or tailored lab-made polymers, and their ability to form well-defined, functional nanoparticles for a variety of applications now and in the past two centuries. Moreover, in combination with high-throughput devices such as microfluidics, pipetting robots, inkjet printers, and automated analytical instrumentation, the abilities of nanoprecipitation may broaden tremendously with significant effects on new applications.

Graphical abstract: Nanoprecipitation and nanoformulation of polymers: from history to powerful possibilities beyond poly(lactic acid)

Article information

Article type
Review Article
Submitted
25 Aug 2010
Accepted
01 Oct 2010
First published
05 Nov 2010

Soft Matter, 2011,7, 1581-1588

Nanoprecipitation and nanoformulation of polymers: from history to powerful possibilities beyond poly(lactic acid)

S. Schubert, J. T. Delaney, Jr and U. S. Schubert, Soft Matter, 2011, 7, 1581 DOI: 10.1039/C0SM00862A

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