Issue 9, 2011
From the journal:

Analyst

Dual-fluorophore ratiometric pH nanosensor with tuneable pKa and extended dynamic range†

Veeren M. Chauhan,a   Gary R. Burnettb  and  Jonathan W. Aylott*a  

* Corresponding authors

a Laboratory of Biophysics and Surface Analysis, School of Pharmacy, Boots Sciences Building, University Park, Nottingham, UK
E-mail: jon.aylott@nottingham.ac.uk
Fax: +44 (0)115 9515102
Tel: +44 (0)115 9516229

b GlaxoSmithKline Consumer Health, St Georges Avenue, Weybridge, UK

Abstract

Ratiometric pH nanosensors with tuneable pKa were prepared by entrapping combinations of two pH-sensitive fluorophores (fluorescein isothiocyanate dextran (FITC-D) and Oregon Green®dextran (OG-D)) and a reference fluorophore (5-(and-6)-carboxytetramethylrhodamine dextran (TAMRA-D)), in a biocompatible polymer matrix. Dual-fluorophore pH nanosensors permit the measurement of an extended dynamic range, from pH 4.0 to 7.5.

Graphical abstract: Dual-fluorophore ratiometric pH nanosensor with tuneable pKa and extended dynamic range

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Article information

DOI
https://doi.org/10.1039/C1AN15042A
Article type
Communication
Submitted
17 Jan 2011
Accepted
01 Mar 2011
First published
18 Mar 2011
This article is Open Access
Creative Commons BY license

Analyst, 2011,136, 1799-1801

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Dual-fluorophore ratiometric pH nanosensor with tuneable pKa and extended dynamic range

V. M. Chauhan, G. R. Burnett and J. W. Aylott, Analyst, 2011, 136, 1799 DOI: 10.1039/C1AN15042A

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