Issue 18, 2011
From the journal:

Chemical Communications

Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery†

Kevin C.-W. Wu,*ab   Yusuke Yamauchi,c   Chen-Yu Hong,a   Ya-Huei Yang,a   Yung-He Liang,a   Takashi Funatsud  and  Makoto Tsunodad  

* Corresponding authors

a Department of Chemical Engineering, National Taiwan University. No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan
E-mail: kevinwu@ntu.edu.tw
Fax: +886 2 2362 3040
Tel: +886 2 3366 3064

b Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan

c World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan

d Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract

Mesoporous titania nanoparticles (MTNs) with excellent biocompatibility (LC50 ≈ 400 μg mL−1) and a large surface area (ca. 237.3 m2 g−1) were synthesized and further functionalized with a phosphate-containing fluorescent molecule (i.e.flavin mononucleotide; FMN) and loaded with an anticancer drug (i.e.Doxorubicin) for successful intracellular bioimaging and drug delivery, respectively, in human breast cancer cells BT-20.

Graphical abstract: Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery

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Article information

DOI
https://doi.org/10.1039/C1CC10659G
Article type
Communication
Submitted
02 Feb 2011
Accepted
11 Mar 2011
First published
31 Mar 2011

Chem. Commun., 2011,47, 5232-5234

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Biocompatible, surface functionalized mesoporous titania nanoparticles for intracellular imaging and anticancer drug delivery

K. C.-W. Wu, Y. Yamauchi, C. Hong, Y. Yang, Y. Liang, T. Funatsu and M. Tsunoda, Chem. Commun., 2011, 47, 5232 DOI: 10.1039/C1CC10659G

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