Issue 18, 2011
From the journal:

Chemical Communications

An iminocoumarin–Cu(ii) ensemble-based chemodosimeter toward thiols†

Hyo Sung Jung,a   Ji Hye Han,b   Yoichi Habata,c   Chulhun Kang*b  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr
Fax: +82 2-3290-3121

b The School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea
E-mail: kangch@khu.ac.kr

c Department of Chemistry, Toho University, Chiba, Japan

Abstract

An ‘ensemble’-based fluoregenic chemodosimeter 1–Cu(II) for detection of thiols is reported. Complex 1–Cu(II) sensitively senses thiols followed by hydrolysis to give a marked fluorescence enhancement over other amino acids at pH 7.4 under aqueous media. Confocal microscopic imaging of complex 1–Cu(II) is also herewith demonstrated for cellular thiol detection in HepG2 cells.

Graphical abstract: An iminocoumarin–Cu(ii) ensemble-based chemodosimeter toward thiols

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Article information

DOI
https://doi.org/10.1039/C1CC10672D
Article type
Communication
Submitted
03 Feb 2011
Accepted
23 Feb 2011
First published
15 Mar 2011

Chem. Commun., 2011,47, 5142-5144

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An iminocoumarin–Cu(II) ensemble-based chemodosimeter toward thiols

H. S. Jung, J. H. Han, Y. Habata, C. Kang and J. S. Kim, Chem. Commun., 2011, 47, 5142 DOI: 10.1039/C1CC10672D

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