Issue 16, 2011
From the journal:

Chemical Communications

Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties†

Hui He,a   Pui-Chi Lo,*a   Sin-Lui Yeung,b   Wing-Ping Fongb  and  Dennis K. P. Ng*a  

* Corresponding authors

a Department of Chemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China
E-mail: pclo@cuhk.edu.hk, dkpn@cuhk.edu.hk
Fax: +852 2603 5057

b School of Life Sciences, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China

Abstract

A series of unsymmetrical distyryl BODIPYs have been prepared which function as highly potent photosensitisers with in vitro IC50 values as low as 15 nM. Their cellular uptake, subcellular localisation and photocytotoxicity depend greatly on the styryl substituents.

Graphical abstract: Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties

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Article information

DOI
https://doi.org/10.1039/C1CC10727E
Article type
Communication
Submitted
07 Feb 2011
Accepted
24 Feb 2011
First published
15 Mar 2011

Chem. Commun., 2011,47, 4748-4750

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Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on their in vitro photodynamic properties

H. He, P. Lo, S. Yeung, W. Fong and D. K. P. Ng, Chem. Commun., 2011, 47, 4748 DOI: 10.1039/C1CC10727E

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