Issue 29, 2011

Conjugated polymernanoparticles for small interfering RNA delivery

Abstract

Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier.

Graphical abstract: Conjugated polymer nanoparticles for small interfering RNA delivery

Supplementary files

Article information

Article type
Communication
Submitted
19 Feb 2011
Accepted
08 Jun 2011
First published
22 Jun 2011

Chem. Commun., 2011,47, 8370-8372

Conjugated polymer nanoparticles for small interfering RNA delivery

J. H. Moon, E. Mendez, Y. Kim and A. Kaur, Chem. Commun., 2011, 47, 8370 DOI: 10.1039/C1CC10991J

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