Issue 19, 2011
From the journal:

Chemical Communications

Copper-catalyzed α-amination of aliphatic aldehydes†

Jie-Sheng Tiana  and  Teck-Peng Loh*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore
E-mail: teckpeng@ntu.edu.sg
Fax: +65 6515 8229
Tel: +65 6513 8475

Abstract

A highly efficient copper-catalyzed α-amination of aliphatic aldehydes for the synthesis of α-aminoacetals using secondary amines with readily removable protecting groups as a nitrogen source was developed. This reaction can be operated under very mild conditions, affording the desired products in moderate to good yields.

Graphical abstract: Copper-catalyzed α-amination of aliphatic aldehydes

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Article information

DOI
https://doi.org/10.1039/C1CC11102G
Article type
Communication
Submitted
24 Feb 2011
Accepted
23 Mar 2011
First published
08 Apr 2011

Chem. Commun., 2011,47, 5458-5460

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Copper-catalyzed α-amination of aliphatic aldehydes

J. Tian and T. Loh, Chem. Commun., 2011, 47, 5458 DOI: 10.1039/C1CC11102G

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