Issue 24, 2011
From the journal:

Chemical Communications

Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins†

Dana A. Uhlenheuer,‡a   Jacqui F. Young,‡b   Hoang D. Nguyen,b   Marcel Scheepstraa  and  Luc Brunsveld*ab  

* Corresponding authors

a Laboratory of Chemical Biology, Department of Biomedical Engineering, Technische Universiteit Eindhoven, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands
E-mail: l.brunsveld@tue.nl
Fax: +31 40 247 8367
Tel: +31 40 247 3737

b Chemical Genomics Centre of the Max Planck Society, Otto-Hahn Str 15, 44227 Dortmund, Germany

Abstract

Cucurbit[8]uril is a supramolecular inducer of protein heterodimerization for proteins appended with methylviologen and naphthalene host elements. Two sets of fluorescent protein pairs, which visualize the specific protein assembly process, enabled the interplay of the supramolecular elements with the proteins to be established.

Graphical abstract: Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

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Article information

DOI
https://doi.org/10.1039/C1CC11197C
Article type
Communication
Submitted
28 Feb 2011
Accepted
05 Apr 2011
First published
18 Apr 2011

Chem. Commun., 2011,47, 6798-6800

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Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

D. A. Uhlenheuer, J. F. Young, H. D. Nguyen, M. Scheepstra and L. Brunsveld, Chem. Commun., 2011, 47, 6798 DOI: 10.1039/C1CC11197C

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