Issue 23, 2011

Synthesis of β- and γ-carbolines viaruthenium and rhodium catalysed [2+2+2] cycloadditions of yne-ynamides with methylcyanoformate

Abstract

A flexible approach towards substituted β- and γ-carbolines based on transition metal catalysed [2+2+2] cycloaddition reactions between functionalised yne-ynamides and methylcyanoformate is described. The versatility of this new reaction sequence is demonstrated by its application in the total synthesis of the marine natural product eudistomin U.

Graphical abstract: Synthesis of β- and γ-carbolines via ruthenium and rhodium catalysed [2+2+2] cycloadditions of yne-ynamides with methylcyanoformate

Supplementary files

Article information

Article type
Communication
Submitted
04 Mar 2011
Accepted
30 Mar 2011
First published
19 Apr 2011

Chem. Commun., 2011,47, 6656-6658

Synthesis of β- and γ-carbolines via ruthenium and rhodium catalysed [2+2+2] cycloadditions of yne-ynamides with methylcyanoformate

F. Nissen, V. Richard, C. Alayrac and B. Witulski, Chem. Commun., 2011, 47, 6656 DOI: 10.1039/C1CC11298H

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