Issue 23, 2011

Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

Abstract

The conjugation of arginine residues at the ends of a metallo-supramolecular triple-helical cylinder enables absolute control over the helicity of the cylinder core, and boosts the DNA junction recognition by the complexes and their activity against a cancer cell line.

Graphical abstract: Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

Supplementary files

Article information

Article type
Communication
Submitted
08 Mar 2011
Accepted
20 Apr 2011
First published
09 May 2011

Chem. Commun., 2011,47, 6575-6577

Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

L. Cardo, V. Sadovnikova, S. Phongtongpasuk, N. J. Hodges and M. J. Hannon, Chem. Commun., 2011, 47, 6575 DOI: 10.1039/C1CC11356A

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