Issue 21, 2011
From the journal:

Chemical Communications

Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues†

Yasutaka Anraku,a   Akihiro Kishimura,*a   Atsushi Kobayashi,a   Makoto Obab  and  Kazunori Kataoka*abcd  

* Corresponding authors

a Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: kishimura@bmw.t.u-tokyo.ac.jp, kataoka@bmw.t.u-tokyo.ac.jp
Fax: +81 3 5841 7139
Tel: +81 3 5841 7109

b Department of Clinical Vascular Regeneration, Graduation School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

c Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

d CREST, Japan Science and Technology Agency, Sanbancho 5, Chiyoda-ku, Tokyo, Japan

Abstract

Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (∼150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler.

Graphical abstract: Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

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Article information

DOI
https://doi.org/10.1039/C1CC11465D
Article type
Communication
Submitted
14 Mar 2011
Accepted
09 Apr 2011
First published
26 Apr 2011

Chem. Commun., 2011,47, 6054-6056

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Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

Y. Anraku, A. Kishimura, A. Kobayashi, M. Oba and K. Kataoka, Chem. Commun., 2011, 47, 6054 DOI: 10.1039/C1CC11465D

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