Issue 23, 2011

The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

Abstract

A palladium-catalyzed cyanation of the 3-position of indole sp2 C–H bonds by the combination of NH4HCO3 and DMSO as the “CN” source was achieved to provide aromatic nitriles in moderate to good yields with excellent regioselectivity. It represents a practical and safe cyanation method.

Graphical abstract: The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

Supplementary files

Article information

Article type
Communication
Submitted
20 Mar 2011
Accepted
19 Apr 2011
First published
10 May 2011

Chem. Commun., 2011,47, 6725-6727

The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

X. Ren, J. Chen, F. Chen and J. Cheng, Chem. Commun., 2011, 47, 6725 DOI: 10.1039/C1CC11603G

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