Issue 37, 2011
From the journal:

Chemical Communications

Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen†

Chaofeng Dai,a   Lisa H. Cazares,b   Lifang Wang,a   Yong Chu,ac   Siming L. Wang,a   Dean A. Troyer,b   O. John Semmes,b   Richard R. Drake*b  and  Binghe Wang*a  

* Corresponding authors

a Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302-4098, USA
E-mail: wang@gsu.edu
Tel: +1 404-413-5544; +1 404-413-5888

b Department of Microbiology and Molecular Cell Biology and The Leroy T. Canoles Jr. Cancer Research Center, Eastern Virginia Medical School, Norfolk, Virginia, USA
E-mail: drakerr@evms.edu

c Department of Medicinal Chemistry, School of Pharmacy, Fudan University, No.826, Zhangheng Rd, Shanghai, China

Abstract

Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin–MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.

Graphical abstract: Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

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Article information

DOI
https://doi.org/10.1039/C1CC11814E
Article type
Communication
Submitted
30 Mar 2011
Accepted
04 Aug 2011
First published
19 Aug 2011

Chem. Commun., 2011,47, 10338-10340

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Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen

C. Dai, L. H. Cazares, L. Wang, Y. Chu, S. L. Wang, D. A. Troyer, O. J. Semmes, R. R. Drake and B. Wang, Chem. Commun., 2011, 47, 10338 DOI: 10.1039/C1CC11814E

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