Issue 25, 2011
From the journal:

Chemical Communications

Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin†

Yujiang Mei,‡a   Christopher J. Frederickson,b   Leonard J. Giblin,b   John H. Weiss,c   Yuliya Medvedevac  and  Paul A. Bentley*a  

* Corresponding authors

a Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, USA
E-mail: pabco21@gmail.com

b NeuroBioTex, 101, Christopher Columbus Blvd., Galveston, Texas, USA

c Department of Anatomy and Neurobiology, School of Medicine, University of California, Med Surge II, Room 364, Irvine, USA

Abstract

A new class of in vitroZn(II) chemosensor based on dipyrrin has been developed. 5-(Pyren-1-yl)-4,6-dipyrrin (PYDPY1) was synthesized and exhibited high selectivity and sensitivity to Zn(II) (Kd of 20 μM) compared to other metal ions. PYDPY1 was applied to the visualization of Zn(II) concentration in hippocampal tissue.

Graphical abstract: Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin

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Article information

DOI
https://doi.org/10.1039/C1CC12181B
Article type
Communication
Submitted
14 Sep 2010
Accepted
19 Apr 2011
First published
26 May 2011

Chem. Commun., 2011,47, 7107-7109

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Sensitive and selective detection of zinc ions in neuronal vesicles using PYDPY1, a simple turn-on dipyrrin

Y. Mei, C. J. Frederickson, L. J. Giblin, J. H. Weiss, Y. Medvedeva and P. A. Bentley, Chem. Commun., 2011, 47, 7107 DOI: 10.1039/C1CC12181B

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