Issue 26, 2011

Unexpected phosphodiesterase activity at low pH of a dinuclear copper–β-cyclodextrin complex

Abstract

A surprisingly low pKa (4.3) for a Cu(II) bridging water was found in the presented complex, Cu22L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn22L at typical lysosomal pH (∼5.0).

Graphical abstract: Unexpected phosphodiesterase activity at low pH of a dinuclear copper–β-cyclodextrin complex

Supplementary files

Article information

Article type
Communication
Submitted
27 Apr 2011
Accepted
20 May 2011
First published
03 Jun 2011

Chem. Commun., 2011,47, 7344-7346

Unexpected phosphodiesterase activity at low pH of a dinuclear copper–β-cyclodextrin complex

M. Zhao, H. Wang, L. Zhang, C. Zhao, L. Ji and Z. Mao, Chem. Commun., 2011, 47, 7344 DOI: 10.1039/C1CC12466H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements