Issue 32, 2011
From the journal:

Chemical Communications

A bifunctional spiro-type organocatalyst with high enantiocontrol: application to the aza-Morita–Baylis–Hillman reactions†

Shinobu Takizawa,a   Kimiko Kiriyama,a   Kenta Iekia  and  Hiroaki Sasai*a  

* Corresponding authors

a The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan
E-mail: sasai@sanken.osaka-u.ac.jp
Fax: +81 6 6879 8465
Tel: +81 6 6879 8469

Abstract

A unique spiro-type Brønsted acid–Lewis base organocatalyst has been developed. The new bifunctional organocatalyst promoted aza-Morita–Baylis–Hillman reactions to yield adducts with up to 98% ee.

Graphical abstract: A bifunctional spiro-type organocatalyst with high enantiocontrol: application to the aza-Morita–Baylis–Hillman reactions

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Article information

DOI
https://doi.org/10.1039/C1CC12784E
Article type
Communication
Submitted
12 May 2011
Accepted
04 Jul 2011
First published
18 Jul 2011

Chem. Commun., 2011,47, 9227-9229

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A bifunctional spiro-type organocatalyst with high enantiocontrol: application to the aza-Morita–Baylis–Hillman reactions

S. Takizawa, K. Kiriyama, K. Ieki and H. Sasai, Chem. Commun., 2011, 47, 9227 DOI: 10.1039/C1CC12784E

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