Issue 34, 2011

Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

Abstract

We report a new class of peptide mimetics, α-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, α-AApeptides may emerge as a novel class of antibiotics.

Graphical abstract: Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

Supplementary files

Article information

Article type
Communication
Submitted
20 Jun 2011
Accepted
06 Jul 2011
First published
21 Jul 2011

Chem. Commun., 2011,47, 9729-9731

Non-hemolytic α-AApeptides as antimicrobial peptidomimetics

S. Padhee, Y. Hu, Y. Niu, G. Bai, H. Wu, F. Costanza, L. West, L. Harrington, L. N. Shaw, C. Cao and J. Cai, Chem. Commun., 2011, 47, 9729 DOI: 10.1039/C1CC13684D

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