Issue 40, 2011
From the journal:

Chemical Communications

Recognition of forcible curvature in circular DNA by human topoisomerase I†

Zhaoqi Yang,a   Dawei Li,a   Shuhui Hiew,a   Magdeline Taotao Ng,a   Weixing Yuan,a   Haibin Su,a   Fangwei Shao*a  and  Tianhu Li*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
E-mail: fwshao@ntu.edu.sg; thli@ntu.edu.sg
Fax: +65 6791-1961
Tel: +65 6592-2511

Abstract

A series of forcible curved circular DNAs (cDNAs) were prepared to investigate the recognition features of human Topoisomerase I (hTopo I). The IC50 can be modulated by the curvature degrees of cDNA. In addition, preferential bindings of hTopo I to cDNA with high curvature have been observed by AFM and EMSA.

Graphical abstract: Recognition of forcible curvature in circular DNA by human topoisomerase I

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Article information

DOI
https://doi.org/10.1039/C1CC13904E
Article type
Communication
Submitted
30 Jun 2011
Accepted
01 Sep 2011
First published
16 Sep 2011

Chem. Commun., 2011,47, 11309-11311

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Recognition of forcible curvature in circular DNA by human topoisomerase I

Z. Yang, D. Li, S. Hiew, M. T. Ng, W. Yuan, H. Su, F. Shao and T. Li, Chem. Commun., 2011, 47, 11309 DOI: 10.1039/C1CC13904E

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