A potent antitumor Zn2+ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies

Jing-Han Wen; Cheng-Ying Li; Zhi-Rong Geng; Xiao-Yan Ma; Zhi-Lin Wang

doi:10.1039/C1CC14107D

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A potent antitumor Zn²⁺ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies†

Jing-Han Wen,^a Cheng-Ying Li,^a Zhi-Rong Geng,^a Xiao-Yan Ma^a and Zhi-Lin Wang*^a

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* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: wangzl@nju.edu.cn

Abstract

A Zn²⁺ tetraazamacrocycle complex (2) bearing three naphthalene moieties has been prepared. Complex 2 recognizes, binds and causes damage to DNA, and shows considerable cytotoxicity against human cervical (HeLa), breast (MCF-7) and lung (NCI-H157) cancer cell lines with a different apoptotic pathway from that of cisplatin.

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Article information

DOI: https://doi.org/10.1039/C1CC14107D
Article type: Communication
Submitted: 08 Jul 2011
Accepted: 31 Aug 2011
First published: 13 Sep 2011

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Chem. Commun., 2011,47, 11330-11332

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A potent antitumor Zn²⁺ tetraazamacrocycle complex targeting DNA: the fluorescent recognition, interaction and apoptosis studies

J. Wen, C. Li, Z. Geng, X. Ma and Z. Wang, Chem. Commun., 2011, 47, 11330 DOI: 10.1039/C1CC14107D

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Chemical Communications