Issue 39, 2011

Palladium-catalyzed reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide: an efficient approach to indeno[1,2-c]azepin-3(2H)-ones

Abstract

A novel and efficient route for rapid access to indeno[1,2-c]azepin-3(2H)-ones is described, which proceeds through a palladium-catalyzed tandem reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide in the presence of PPh3 or PCy3. The indeno[1,2-c]azepin-3(2H)-ones which incorporate both indene and unsaturated seven-membered ring lactam skeletons are obtained in good to excellent yields.

Graphical abstract: Palladium-catalyzed reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide: an efficient approach to indeno[1,2-c]azepin-3(2H)-ones

Supplementary files

Article information

Article type
Communication
Submitted
23 Jul 2011
Accepted
25 Aug 2011
First published
06 Sep 2011

Chem. Commun., 2011,47, 11137-11139

Palladium-catalyzed reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide: an efficient approach to indeno[1,2-c]azepin-3(2H)-ones

Y. Luo and J. Wu, Chem. Commun., 2011, 47, 11137 DOI: 10.1039/C1CC14480D

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