Issue 39, 2011

A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine

Abstract

Synthesis of the first self-immobilizing, fluorogenic unnatural amino acid that mimics phosphotyrosine (pTyr) is reported. By using solid-phase peptide synthesis, it was subsequently incorporated into peptide-based probes which found applications in bioimaging and fluorescence-activated cell sorting (FACS).

Graphical abstract: A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine

Supplementary files

Article information

Article type
Communication
Submitted
29 Jul 2011
Accepted
31 Aug 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 10939-10941

A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine

J. Ge, L. Li and S. Q. Yao, Chem. Commun., 2011, 47, 10939 DOI: 10.1039/C1CC14653J

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