Issue 40, 2011

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Abstract

A clickable, affinity-based probe (AfBP), which was modified from staurosporine (a natural product kinase inhibitor), has been synthesized and used in situ for activity-based proteome profiling of potential cellular targets of staurosporine in HepG2 cancer cells.

Graphical abstract: Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Supplementary files

Article information

Article type
Communication
Submitted
04 Aug 2011
Accepted
07 Sep 2011
First published
16 Sep 2011

Chem. Commun., 2011,47, 11306-11308

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

H. Shi, X. Cheng, S. K. Sze and S. Q. Yao, Chem. Commun., 2011, 47, 11306 DOI: 10.1039/C1CC14824A

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