Issue 5, 2012

Direct amide formation from unactivated carboxylic acids and amines

Abstract

The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 °C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.

Graphical abstract: Direct amide formation from unactivated carboxylic acids and amines

Supplementary files

Article information

Article type
Communication
Submitted
22 Aug 2011
Accepted
08 Nov 2011
First published
28 Nov 2011

Chem. Commun., 2012,48, 666-668

Direct amide formation from unactivated carboxylic acids and amines

C. L. Allen, A. R. Chhatwal and J. M. J. Williams, Chem. Commun., 2012, 48, 666 DOI: 10.1039/C1CC15210F

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