Issue 13, 2012

Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

Abstract

A metal complex is identified in which the metal fulfills two independent functions: as a structural scaffold for the specific molecular recognition of protein kinases resulting in antiangiogenic properties, together with a visible-light-induced photoreactivity triggering apopotosis in cancer cells.

Graphical abstract: Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

Supplementary files

Article information

Article type
Communication
Submitted
29 Aug 2011
Accepted
19 Oct 2011
First published
07 Nov 2011

Chem. Commun., 2012,48, 1863-1865

Dual anticancer activity in a single compound: visible-light-induced apoptosis by an antiangiogenic iridium complex

A. Kastl, A. Wilbuer, A. L. Merkel, L. Feng, P. Di Fazio, M. Ocker and E. Meggers, Chem. Commun., 2012, 48, 1863 DOI: 10.1039/C1CC15378A

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