Issue 7, 2012
From the journal:

Chemical Communications

Colorimetric detection of apoptosis based on caspase-3 activity assay using unmodified gold nanoparticles†

Yuliang Pan,a   Manli Guo,*a   Zhou Nie,a   Yan Huang,a   Ying Peng,a   Afang Liu,a   Meng Qinga  and  Shouzhuo Yaoa  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: manliguo_cn@yahoo.com.cn
Fax: +86 731 88821626
Tel: +86 731 88821626

Abstract

A new label-free method for the detection of apoptosis was proposed based on colorimetric assay of caspase-3 activity using an unlabeled Asp-Glu-Val-Asp (DEVD)-containing peptide substrate and unmodified gold nanoparticles (AuNPs).

Graphical abstract: Colorimetric detection of apoptosis based on caspase-3 activity assay using unmodified gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C1CC15407A
Article type
Communication
Submitted
31 Aug 2011
Accepted
14 Nov 2011
First published
05 Dec 2011

Chem. Commun., 2012,48, 997-999

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Colorimetric detection of apoptosis based on caspase-3 activity assay using unmodified gold nanoparticles

Y. Pan, M. Guo, Z. Nie, Y. Huang, Y. Peng, A. Liu, M. Qing and S. Yao, Chem. Commun., 2012, 48, 997 DOI: 10.1039/C1CC15407A

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