Issue 2, 2012
From the journal:

Chemical Communications

Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method†

Liang Cui,a   Xiaoyan Lin,a   Ninghang Lin,a   Yanling Song,a   Zhi Zhu,a   Xi Chena  and  Chaoyong James Yang*a  

* Corresponding authors

a The Key Laboratory of Analytical Science, the Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
E-mail: cyyang@xmu.edu.cn

Abstract

Based on graphene oxide-protected DNA probes, we have developed a cyclic enzymatic amplification method for sensitive miRNA detection in complex biological samples. By using the quenching nature of graphene oxide for multiple fluorophores, this method can distinguish highly similar miRNA sequences and detect them simultaneously.

Graphical abstract: Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method

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Article information

DOI
https://doi.org/10.1039/C1CC15412E
Article type
Communication
Submitted
31 Aug 2011
Accepted
22 Sep 2011
First published
05 Oct 2011

Chem. Commun., 2012,48, 194-196

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Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples based on a cyclic enzymatic amplification method

L. Cui, X. Lin, N. Lin, Y. Song, Z. Zhu, X. Chen and C. J. Yang, Chem. Commun., 2012, 48, 194 DOI: 10.1039/C1CC15412E

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