Issue 46, 2011
From the journal:

Chemical Communications

Inverse electron-demand Diels–Alder reactions for the selective and efficient labeling of RNA†

Juliane Schoch,‡a   Sandeep Ameta‡a  and  Andres Jäschke*a  

* Corresponding authors

a Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany
E-mail: jaeschke@uni-hd.de
Fax: +49 (0)6221 54 6430
Tel: + 49 (0)6221 54 4851

Abstract

We report the first example of RNA labeling based on inverse electron-demand Diels–Alder reactions. Both chemically synthesized and enzymatically transcribed RNAs were successfully modified with biotin or a fluorescent label. This approach works efficiently under mild conditions in water and does not require transition metals.

Graphical abstract: Inverse electron-demand Diels–Alder reactions for the selective and efficient labeling of RNA

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Article information

DOI
https://doi.org/10.1039/C1CC15476A
Article type
Communication
Submitted
02 Sep 2011
Accepted
29 Sep 2011
First published
14 Oct 2011

Chem. Commun., 2011,47, 12536-12537

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Inverse electron-demand Diels–Alder reactions for the selective and efficient labeling of RNA

J. Schoch, S. Ameta and A. Jäschke, Chem. Commun., 2011, 47, 12536 DOI: 10.1039/C1CC15476A

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