Issue 11, 2012

Following aptamer–ricin specific binding by single molecule recognition and force spectroscopy measurements

Abstract

Single molecule recognition imaging and dynamic force spectroscopy (DFS) analysis showed strong binding affinity between an aptamer and ricin, which was comparable with antibody–ricin interaction. Molecular simulation showed a ricin binding conformation with aptamers and gave different ricin conformations immobilizing on substrates that were consistent with AFM images.

Graphical abstract: Following aptamer–ricin specific binding by single molecule recognition and force spectroscopy measurements

Supplementary files

Article information

Article type
Communication
Submitted
12 Sep 2011
Accepted
30 Oct 2011
First published
11 Nov 2011

Chem. Commun., 2012,48, 1644-1646

Following aptamer–ricin specific binding by single molecule recognition and force spectroscopy measurements

B. Wang, C. Guo, G. Chen, B. Park and B. Xu, Chem. Commun., 2012, 48, 1644 DOI: 10.1039/C1CC15644F

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